Finding Functional Sites in Structural Genomics Proteins
نویسندگان
چکیده
منابع مشابه
Finding functional sites in structural genomics proteins.
Assigning function to structures is an important aspect of structural genomics projects, since they frequently provide structures for uncharacterized proteins. Similarities uncovered by structure alignment can suggest a similar function, even in the absence of sequence similarity. For proteins adopting novel folds or those with many functions, this strategy can fail, but functional clues can st...
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Structural genomics is a broad initiative of various centers aiming to provide a complete coverage of protein structure space. Since it is not feasible to experimentally determine the structures of all proteins, it is generally agreed that the only viable strategy to achieve such coverage is to carefully 2 select specific proteins (" targets "), determine their structure experimentally, and the...
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ژورنال
عنوان ژورنال: Structure
سال: 2004
ISSN: 0969-2126
DOI: 10.1016/j.str.2004.05.012